ChemicalBook > CAS DataBase List > 5-Carboxy-8-hydroxyquinoline

5-Carboxy-8-hydroxyquinoline

CAS No.5852-78-8
Chemical Name:5-Carboxy-8-hydroxyquinoline
CBNumber:CB02671446
Molecular Formula:C10H7NO3
Formula Weight:189.17
MOL File:5852-78-8.mol

5-Carboxy-8-hydroxyquinoline Property

Melting point 301 °C (decomp)
Boiling point 464.5±30.0 °C(Predicted)
Density 1.480±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
pka 1.82±0.10(Predicted)
color white to brown
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey JGRPKOGHYBAVMW-UHFFFAOYSA-N
FDA UNII JM015YQC1C
UNSPSC Code 51111800
NACRES NA.77

Safety

Hazard Codes :Xn
Risk Statements :22
WGK Germany :3
HS Code :2933499090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P261-P271-P280

5-Carboxy-8-hydroxyquinoline Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: SML0067
Product name : IOX1
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: ₹12578.65
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: SML0067
Product name : IOX1
Purity: ≥97% (HPLC)
Packaging: 25MG
Price: ₹50780.08
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 420201
Product name : JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem
Purity: The JMJD2 Inhibitor, 5-carboxy-8HQ, also referenced under CAS 5852-78-8, controls the biological activity of JMJD2. This small molecule/inhibitor is p
Packaging: 5MG
Price: ₹19050
Updated: 2022/06/14
Buy: Buy

5-Carboxy-8-hydroxyquinoline Chemical Properties,Usage,Production

Description IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable
Uses 8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
Uses IOX1 has been used:
- To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
- In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
- to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Uses 5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
Definition ChEBI: 8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.
Biochem/physiol Actions IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
storage Store at +4°C
References 1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535