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Mirin

CAS No.299953-00-7
Chemical Name:Mirin
CBNumber:CB02501840
Molecular Formula:C10H8N2O2S
Formula Weight:220.25
MOL File:299953-00-7.mol

Mirin Property

Melting point 295-297 °C(Solv: ethanol (64-17-5))
Boiling point 441.6±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >10mg/mL
form Reddish orange powder
pka 9.15±0.30(Predicted)
color red to orange
Sensitive Moisture Sensitive
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36
Safety Statements :26
WGK Germany :3

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Mirin Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: M9948
Product name : Mirin
Purity: ≥98% (HPLC), powder
Packaging: 5MG
Price: ₹9006.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M9948
Product name : Mirin
Purity: ≥98% (HPLC), powder
Packaging: 25MG
Price: ₹35744.15
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 475954
Product name : MRN-ATM Pathway Inhibitor, Mirin - CAS 299953-00-7 - Calbiochem
Purity: The MRN-ATM Pathway Inhibitor, Mirin, also referenced under CAS 299953-00-7, controls the biological activity of Mre11, component of the MRN (Mre11-Ra
Packaging: 10MG
Price: ₹9490
Updated: 2022/06/14
Buy: Buy

Mirin Chemical Properties,Usage,Production

Description Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC₅₀ value of 66 μM in X. laevis cell-free extracts. Mirin (100 μM) also inhibits the exonuclease activity of Mre11 in a cell-free assay. It induces cell cycle arrest at the G₂ phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner. Nanoparticle-encapsulated mirin (50 mg/kg) reduces tumor growth in an LA-N-5 mouse xenograft model.
Uses Mirin has been used:
- as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
- as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
- in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)
Uses The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]
Biochem/physiol Actions Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.
References 1) Dupre et al. (2008), A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex; Nat. Chem. Biol., 4 119