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CHK2 INHIBITOR II

CAS No.516480-79-8
Chemical Name:CHK2 INHIBITOR II
CBNumber:CB9503256
Molecular Formula:C20H14ClN3O2
Formula Weight:363.8
MOL File:516480-79-8.mol

CHK2 INHIBITOR II Property

Boiling point 637.1±63.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 18 mg/mL
form solid
pka 10.40±0.10(Predicted)
color tan
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
UNSPSC Code 12352200
NACRES NA.77

Safety

WGK Germany :3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P305+P351+P338

CHK2 INHIBITOR II Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: C3742
Product name : Chk2 Inhibitor II hydrate
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: ₹19701.5
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C3742
Product name : Chk2 Inhibitor II hydrate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: ₹75244.58
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 220491
Product name : InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
Purity: The InSolution Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is pr
Packaging: 5MG
Price: ₹20250
Updated: 2022/06/14
Buy: Buy

CHK2 INHIBITOR II Chemical Properties,Usage,Production

Description Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC₅₀ = 15 nM). It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC₅₀ = 3-7.6 μM). This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.
Uses Chk2 Inhibitor II is a selective APT-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).
Biochem/physiol Actions Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC50 = 15 nM; Ki = 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC50 = 3 μM and 7.6 μM, respectively).
References 1) Arienti et al. (2005), Checkpoint kinases inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles; J. Med. Chem., 48 1873 2) Pereg et al. (2006), Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage; Mol. Cell. Biol., 26 6819