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Xamoterol hemifumarate

Xamoterol hemifumarate Structure
Xamoterol hemifumarate
  • CAS No.73210-73-8
  • Chemical Name:Xamoterol hemifumarate
  • CBNumber:CB0249700
  • Molecular Formula:C36H54N6O14
  • Formula Weight:794.85
  • MOL File:73210-73-8.mol
Xamoterol hemifumarate Property
  • Melting point 168-169° (dec)
  • storage temp. Store at RT
  • solubility H2O: 10 mg/mL at 60 °C, soluble
  • form solid
  • color white
  • CAS DataBase Reference 73210-73-8
  • FDA UNII N87007N668
  • ATC code C01CX07
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H361
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501

Xamoterol hemifumarate Chemical Properties,Usage,Production

  • Description Xamoterol fumarate is a cardioselective partial beta-agonist, the first of its class to be developed for use in heart failure. The main advantage of xamoterol fumarate as a cardiotonic lies in the fact that its beta-blocking effect exerted during high sympathetic drive will protect the heart from overstimulation. It is claimed to be a viable but safer alternative to digoxin.
  • Description Xamoterol is a partial agonist of β1-adrenergic receptors (β1-ARs) with an EC50 value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM). In vivo, xamoterol increases heart rate in beagle dogs (ED50 = 3.2 μg/kg) and in a rat model of spontaneous heart failure (ED50 = 6 μg/kg), an effect that is reversed by the selective β1-AR antagonist betaxolol but not the selective β2-AR antagonist ICI 118551 . Formulations containing xamoterol have been used in the treatment of heart failure.
  • Originator ICI (United Kingdom)
  • Uses Xamoterol Hemifumarate, is a β1-adrenoceptor-selective partial agonist.
  • Uses Stimulant (cardiac).
  • brand name Corwin
  • Biological Activity β 1 -adrenoceptor-selective partial agonist (pA 2 values are 7.4-7.8 and 5.2-6.2 at β 1 - and β 2 -adrenoceptors respectively).
  • storage Store at RT
Xamoterol hemifumarate Preparation Products And Raw materials
Raw materials
Preparation Products
Xamoterol hemifumarate Suppliers
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Xamoterol hemifumarate Spectrum
73210-73-8, Xamoterol hemifumarateRelated Search:
  • API
  • ICI 118,587
  • 抑制剂
  • 药靶配体
  • 药物
  • 心脑血管药物
  • 强心药
  • C16H25N3O512C4H4O4
  • C16H25N3O505C4H4O4
  • 2C16H25N3O5C4H4O4
  • XAMOTEROL HEMIFUMARATE,BETA1-ADRENOCEPTOR-SELECTIVE PARTIAL激动剂
  • XAMOTEROL HEMIFUMARATE,Β1-肾上腺素受体部分激动剂
  • 化合物 T23536
  • 扎莫特罗半富马酸盐
  • 1-(对羟苯氧基)-3-[2-(吗啉酰胺基)乙氨基]-2-丙醇半富马酸盐
  • 半富马酸扎莫特罗
  • 富马酸扎莫特罗
  • 73210-73-8
  • 4-Morpholinecarboxamide, N-[2-[[2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-, (E)-2-butenedioate (2:1)
  • Xamoterol hemifumarate, beta1-adrenoceptor-selective partial agonist
  • Alfuzosin Impurity 9
  • Xamoterol hemifumara
  • QEDVGROSOZBGOZ-WXXKFALUSA-N
  • N-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)aMino)ethyl)Morpholine-4-carboxaMide
  • 1-(4-HYDROXYPHENOXY)-3-[2-(4-MORPHOLINOCARBOXAMIDO)ETHYLAMINO]-2-PROPANOL HEMIFUMARATE
  • (+/-)-N-[2-[[HYDROXY-3-(4-HYDROXY)PROPYL]AMINO]ETHYL-4-MORPHOLINECARBOXAMIDE HEMIFUMARATE SALT
  • XAMOTEROL HEMIFUMARATE SALT
  • XAMOTEROL HEMIFUMARATE
  • XAMOTEROL
  • Xamtol
  • ICI-118587
  • Corwin：Xamtol
  • Carwin
  • Corwin
  • ICI 118587 hemifumarate salt, (±)-N-[2-[[Hydroxy-3-(4-hydroxy)propyl]amino]ethyl-4-morpholinecarboxamide hemifumarate salt
  • bis[N-[2-[[2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]morpholine-4-carboxamide] fumarate
  • ICI 118587 HEMIFUMARATE SALT

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