73210-73-8

Xamoterol fumarate is a cardioselective partial beta-agonist, the first of its class to be developed for use in heart failure. The main advantage of xamoterol fumarate as a cardiotonic lies in the fact that its beta-blocking effect exerted during high sympathetic drive will protect the heart from overstimulation. It is claimed to be a viable but safer alternative to digoxin.

Crystallizes in ethanol, melting point 168-169℃ (decomposition).

ICI (United Kingdom)

Stimulant (cardiac).

Corwin

β 1 -adrenoceptor-selective partial agonist (pA 2 values are 7.4-7.8 and 5.2-6.2 at β 1 - and β 2 -adrenoceptors respectively).

Store at RT

[1] R N WILLETTE. In vitro and in vivo characterization of intrinsic sympathomimetic activity in normal and heart failure rats.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 289 1: 48-53.
[2] M T KOWALSKI. Comparison of the effects of xamoterol and isoprenaline on rat cardiac beta-adrenoceptors: studies of function and regulation.[J]. British Journal of Pharmacology, 1990, 99 1: 27-30. DOI: 10.1111/j.1476-5381.1990.tb14648.x
[3] A. NUTTALL  H. M S. THE CARDIOVASCULAR EFFECTS OF ICI 118,587: A β1-ADRENOCEPTOR PARTIAL AGONIST[J]. British Journal of Pharmacology, 1982, 77 2: 381-388. DOI: 10.1111/j.1476-5381.1982.tb09309.x