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Dehydroepiandrosterone acetate

CAS No.853-23-6
Chemical Name:Dehydroepiandrosterone acetate
CBNumber:CB0247928
Molecular Formula:C21H30O3
Formula Weight:330.47
MOL File:853-23-6.mol

Dehydroepiandrosterone acetate Property

Melting point 168-170 °C(lit.)
Boiling point 407.89°C (rough estimate)
Density 1.0998 (rough estimate)
vapor pressure 0Pa at 20℃
refractive index 1.5192 (estimate)
storage temp. Refrigerator
solubility Chloroform, DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
optical activity [α]20/D +2.4°, c = 2 in ethanol
Water Solubility 11.5mg/L(temperature not stated)
InChI InChI=1/C21H30O3/c1-13(22)24-15-8-10-20(2)14(12-15)4-5-16-17-6-7-19(23)21(17,3)11-9-18(16)20/h4,15-18H,5-12H2,1-3H3/t15-,16-,17-,18-,20-,21-/s3
InChIKey NCMZQTLCXHGLOK-KJBVPOJVSA-N
SMILES C[C@]12CC[C@H](OC(=O)C)CC1=CC[C@@]1([H])[C@]3([H])CCC(=O)[C@@]3(C)CC[C@]21[H] |&1:1,4,13,15,21,25,r|
LogP 5.1 at 20℃
CAS DataBase Reference 853-23-6
FDA UNII 45751H45MY

Safety

Safety Statements :22-24/25
WGK Germany :3
RTECS :BV8396810

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H360
Precautionary statements

Dehydroepiandrosterone acetate Chemical Properties,Usage,Production

Chemical Properties Off-White Solid
Uses A metabolite of Dehydroepiandrosterone. This mammalian pro-hormone promotes brain and immune function
Uses Menopausal syndrome
Definition ChEBI: Prasterone acetate is a steroid ester.
Application Dehydroepiandrosterone acetate (CAS No: 853-23-6, abbreviated as DHEA acetate) is an important pharmaceutical intermediate. It can be used as a raw material to produce testosterone, methyl testosterone, estradiol, and estriol. Recently, with the development of the pharmaceutical industry, more and more applications for DHEA acetate have been exploited[1].
Flammability and Explosibility Not classified
Biological Activity Dehydroepiandrosterone acetate (DHEA, Androstenolone) is a kind of dehydroepiandrosterone derivatives. DHEA is an endogenous steroid hormone, which is considered to be a natural product/dietary supplement with many proposed benefits to humans.
in vivo Dehydroisoandrosterone implants increases aggression in a laboratory-based simulated territorial intrusion. Brains of Dehydroisoandrosterone-implanted birds show higher aromatase mRNA expression in the preoptic area (POA) and higher androgen receptor mRNA expression in the periventricular nucleus of the medial striatum (pvMSt) and ventromedial nucleus of the hypothalamus (VMH). The Dehydroisoandrosterone-induced increases in aromatase expression in the POA and androgen receptor expression in the pvMSt are consistent with previously reported seasonal increases in these markers associated with naturally elevated Dehydroisoandrosterone levels. Dehydroisoandrosterone supplementation (10.2 mg/kg) alone significantly increases mice body weight (BW), muscle weight, testosterone level, and glycogen contents (liver and muscle) when compared with SC group.
References [1] Chao Cheng. “Solubility determination and thermodynamic models for dehydroepiandrosterone acetate in mixed solvents of (ethyl acetate + methanol), (ethyl acetate + ethanol) and (ethyl acetate + isopropanol).” Journal of Chemical Thermodynamics 101 (2016): Pages 372-379.