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UTP

UTP Structure
UTP
  • CAS No.63-39-8
  • Chemical Name:UTP
  • CBNumber:CB0221667
  • Molecular Formula:C9H15N2O15P3
  • Formula Weight:484.14
  • MOL File:63-39-8.mol
UTP Property
  • Density 2.106±0.06 g/cm3(Predicted)
  • Flash point 113 °C
  • storage temp. Sealed in dry,2-8°C
  • solubility Easily soluble (water)
  • form liquid
  • pka pK1:7.58 (25°C)
  • color colorless
  • biological source yeast (Candida Utilis)
  • Water Solubility Water : ≥ 150 mg/mL (309.83 mM)
  • CAS DataBase Reference 63-39-8(CAS DataBase Reference)
  • FDA UNII UT0S826Z60
  • EPA Substance Registry System Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)
  • UNSPSC Code 41106305
  • NACRES NA.52
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
UTP Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: U1006
  • Product name : Uridine 5′-triphosphate trisodium salt solution
  • Purity: HPLC purified, aqueous solution for RNA polymerase transcription
  • Packaging: 25μMOL
  • Price: ₹12113.18
  • Updated: 2022/06/14
  • Buy: Buy

UTP Chemical Properties,Usage,Production

  • Description Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
  • Occurrence Uridine 5'-triphosphate is a natural product found in Helianthus tuberosus, Apis cerana, and other organisms with data available.
  • Uses Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).
  • Definition UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).
  • Biochem/physiol Actions P2Y receptor agonist
  • Pharmacokinetics INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway.
  • in vitro Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.
  • in vivo Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.
  • References [1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.
    [2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.
    [3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
    [4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.
UTP Preparation Products And Raw materials
Raw materials
Preparation Products
UTP Suppliers
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UTP Spectrum
63-39-8, UTPRelated Search:
  • Elisa Kit-plant ELISA Kit
  • NTP
  • 医用原料
  • 核苷酸极其类似物-尿苷三磷酸
  • 对照品-杂质对照品
  • DNA / RNA Synthesis
  • Nucleotides
  • C9H15N2O15P3
  • 假尿苷三磷酸三羟甲基氨基甲烷溶液
  • 尿苷三磷酸三羟甲基氨基甲烷溶液
  • N1-甲基假尿苷三磷酸三羟甲基氨基甲烷溶液
  • 尿苷5'-三磷酸锂盐
  • ((2R,3S,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-3,4-二羟四氢呋喃-2-基)甲基三磷酸四氢原
  • 尿苷-5'-三磷酸 (UTP)
  • 植物三磷酸尿苷ELISA试剂盒
  • MIX OF 25 MM ATP, CTP, GTP AND UTP ADENOSINE-5'-TRIPHOSPHATE, SODIUM SALT; CYTIDINE-5'-TRIPHOSPHATE, SODIUM SALT; GUANOSINE-5'-TRIPHOSPHATE, SODIUM SALT; URIDINE-5'-TRIPHOSPHATE, SODIUM SALT
  • 二喹福索杂质B
  • 尿苷5'-三磷酸盐,锂盐(U-13C9,98%
  • U-15N2,98%)化学纯度> 90%(在固体中)
  • 尿苷5'-三磷酸锂盐(13C9,98%
  • 15N2,96-98%)90-95%纯度
  • 二喹唑醇杂质B
  • 三磷酸尿酐二钠(UTP)
  • 地夸磷索杂质B
  • 尿苷-5′-三磷酸酯 三钠盐 溶液
  • 尿苷5'-三磷酸酯
  • 尿苷-5-三磷酸钠盐
  • 尿苷-5'-三磷酸
  • 尿苷三磷酸
  • UTP【尿苷三磷酸】
  • 63-39-8
  • Uridine 5'-triphosphate
  • Uridine 5'-(tetrahydrogen triphosphate)
  • UTP Sodium Solution,UltraNUcTM?NTPs
  • UTP 200mM Tris Solution
  • UTP 200mM Tris Solution, GMP grade
  • UTP Sodium
  • triphosphoric acid 1-uridin-5'-yl ester
  • ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
  • UTP Solution (100mM)
  • UTP TRISODIUM SALT
  • UTP-NA
  • Uridine-5'-triphosphate Free acid
  • Mix of 25 mM ATP, CTP, GTP and UTP Adenosine-5'-triphosphate, Sodium salt
  • UTP .Free Acid
  • Urd-5'-P3
  • pppU
  • Uridine 5μ-triphosphate solution trisodium salt
  • Uridine-5''-triphosphoric acid (and/or unspecified salts)
  • 5'-uridylate triphosphate (UTP)
  • [[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
  • Uracylic
  • Uridine 5′-triphosphate trisodium salt solution
  • ({[(2S,3R,4S,5S)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)-3,4-dihydroxyoxolan-2-yl]Methyl phosphonato}oxy)(phosphonatooxy)phosphinate
  • uteplex
  • uridinetriphosphate
  • uridine5’-triphosphoricacid
  • uridine,5’-(tetrahydrogentriphosphate)

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