Description
Uridine-5'-triphosphoric acid trisodium salt, also known as UTP, is a polyphosphate analogue of uridine that is used in the synthesis of agonists at the G-protein-coupled P2Y receptors.
Chemical Properties
White crystalline powder
Uses
Uridine-5'-triphosphoric acid trisodium salt is a polyphosphate analogue of the nucleoside uridine used in the preparation of potent and selective agonists at the G-protein-coupled P2Y receptors.
Uses
P2Y receptor agonist.
Application
Uridine-5'-triphosphoric acid trisodium salt solution can be used to increase intracellular Ca2+ levels in rat primary tracheal epithelial cells. It is also used as a nucleotide substrate to analyze the activity of MutT homolog 1 (MTH1).
General Description
Uridine 5’-triphosphate trisodium salt (UTP-Na3) is not only an essential substance for intracellular RNA synthesis and energy metabolism, but also an important extracellular signaling molecule that finely regulates a variety of key physiological functions such as inflammation, tissue repair and secretion by activating P2Y receptors.
Biochem/physiol Actions
Uridine-5′-Triphosphate(UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space. Uridine-5′-Triphosphate(UTP) is involved in various pathophysiological responses in the nervous system.UTP also plays a major role in the regeneration process.
in vitro
Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 μM; 2, 4, 6, 8, 10, and 12 h) trisodium salt enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate trisodium salt induces Schwannoma cell migration through the activation of P2Y2 receptors and the increase of extracellular MMP-2 activation and expression. Uridine triphosphate (UTP) trisodium salt (Uridine-5'-triphosphoric acid trisodium salt) evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h.
Structure and conformation
Uridine-5'-triphosphoric acid trisodium salt is composed of uridine (a nucleoside) combined with three phosphate groups and exists in the form of trisodium salt. This structure makes it well soluble in aqueous solution, and the negatively charged phosphate groups can participate in a variety of important energy transfer processes in biochemical reactions.
