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J&J Ex-61

J&J Ex-61 Structure
J&J Ex-61
  • CAS No.943540-75-8
  • Chemical Name:J&J Ex-61
  • CBNumber:CB01872310
  • Molecular Formula:C19H13F2N7
  • Formula Weight:377.35
  • MOL File:943540-75-8.mol
J&J Ex-61 Property
  • Density 1.50
  • storage temp. Store at -20°C
  • solubility insoluble in H2O; ≥18.85 mg/mL in DMSO; ≥3.25 mg/mL in EtOH with ultrasonic
  • form Powder
  • pka 3.92±0.10(Predicted)
  • color Off-white to light yellow
  • CAS DataBase Reference 943540-75-8
  • FDA UNII 15UDG410PN
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319-H317
  • Precautionary statements P261-P264-P272-P280-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501

J&J Ex-61 Chemical Properties,Usage,Production

  • Uses JNJ-38877605 is a potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.
  • Definition ChEBI: 6-[difluoro-[6-(1-methyl-4-pyrazolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline is a member of quinolines.
  • Biological Activity jnj-38877605 is a small-molecule atp-competitive inhibitor of the catalytic activity of c-met.extensive evidence that c-met signaling is involved in the progression and spread of several cancers and an enhanced understanding of its role in disease have generated considerable interest in c-met and hgf asmajor targets in anti-cancer drug development.
  • in vitro jnj-38877605 showed ~600-fold selectivity for c-met compared with a panel of ~250 diverse tyrosine and serine-threonine kinases and was found to potently inhibit hgf-stimulated and constitutively activated c-met phosphorylation in vitro [1].
  • in vivo jnj-38877605 showed excellent oral bioavailability approaching 100% in all examined species. in addition, jnj-38877605 in a single dose was observed toinhibit met phosphorylation in tumor xenografts for up to16 h. inhibition of met phosphorylation was associated withdose-dependent tumor growth inhibition using a range of oral dosing regimens [2].
  • target c-Met
  • References [1] pererat, l avrijssent, janssens b, et al. jnj-38877605: a selective met kinase inhibitor inducingregression of met-driven tumor models. presented at the 99th aacr annual meeting; 2008 apr 12 -16;
J&J Ex-61 Preparation Products And Raw materials
Raw materials
Preparation Products
J&J Ex-61 Suppliers
Global(137)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
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    Biochempartner
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  • Supplier：
    TargetMol Chemicals Inc.
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    Career Henan Chemica Co
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  • Country：China
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J&J Ex-61 Spectrum
943540-75-8, J&J Ex-61Related Search:
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 药靶配体
  • 合成材料中间体-高分子材料
  • 小分子抑制剂，天然产物
  • 蛋白酪氨酸激酶
  • 杂环
  • 芳烃衍生物
  • C19H13F2N7
  • 943540-74-1
  • 化合物JNJ38877605,10 MM DMSO 溶液
  • JNJ-38877605,C-MET抑制剂
  • 化合物JNJ38877605
  • 6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-噻唑并[4,3-B]吡嗪-3-基]甲基]-喹啉
  • 6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪-3-基]甲基]喹啉
  • 6-[二氟[6-(1-甲基-1H-吡唑-4-基)-1,2,4-三唑并[4,3-B]哒嗪-3
  • 943540-75-8
  • JNJ-38877605, 10 mM in DMSO
  • Venadaparib Impurity 19
  • 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[3,4-f]...
  • J&J Ex-61 USP/EP/BP
  • 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[3,4-f]pyridazin-3-yl]methyl]quinoline
  • JNJ38877605; JNJ-38877605
  • CS-43
  • 6-[difluoro-[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
  • JNJ 38877605 NEW
  • JNJ 38877605 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
  • 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline JNJ 38877605
  • JNJ-33877605
  • JNJ-38877605
  • 6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]-triazolo[4,3-b]pyridazin-3-yl)methyl)quinolin
  • 6-[Difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline
  • Quinoline, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-
  • J&J Ex-61

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