ChemicalBook > CAS DataBase List > 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Structure
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
  • CAS No.905854-02-6
  • Chemical Name:3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
  • CBNumber:CB82123239
  • Molecular Formula:C23H19N3O2
  • Formula Weight:369.42
  • MOL File:905854-02-6.mol
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Property
  • Boiling point 715.9±60.0 °C(Predicted)
  • Density 1.49
  • storage temp. -20°C Freezer, Under inert atmosphere
  • solubility DMSO (Slightly), Methanol (Slightly)
  • pka 9.28±0.70(Predicted)
  • form Solid
  • color Light Orange
  • FDA UNII PJ4H73IL17
  • NCI Drug Dictionary tivantinib
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H373-H360
  • Precautionary statements P260-P314-P501

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Chemical Properties,Usage,Production

  • Uses Tivantinib is a hepatocyte growth factor receptor (proto-oncogene c-Met; MET) inhibitor. Tivantinib inhibits human c-Met receptor tyrosine kinase selectively and is a promising therapeutic option for the treatment of c-Met-associated cancers. Potent c-MET inhibitor.
  • Definition ChEBI: LSM-1131 is a member of indoles.
  • Biological Activity tivantinib (arq 197) is an oral, non–adenosine triphosphate-competitive, selective, small-molecule met proto-oncogene (c-met) inhibitor. the calculated inhibitory constant (ki) for tivantinib to inhibit recombinant human c-met was approximately 355 nmol/l.c-met, a type of receptor tyrosine kinase, is a high-affinity receptor of the hepatocyte growth factor (hgf). dysregulated hgf/c-met-signaling pathway frequently occurs in human cancer [1].tivantinib had weak inhibitory effects on vegf receptor-3 (flt4), p21-activated kinase 3, calmodulin-dependent kinase ii delta, and pim-1 [1]. tivantinib displayed cytotoxic activity against a wide panel of human tumor cell lines with an ec50 ranging from 300-600 nmol/l [4]. remarkably, a549, h3122, pc9 (del e746_a750), pc9 gr4 (del e746_a750/t790m), hcc827, hcc827 gr6, h1993 and ebc-1 cell lines showed some degree of sensitivity to tivantinib, with ic50s ranging between 0.36 and 0.8 μm [5]. in tumor cell lines, gtl-16, mkn-45, hs746t, snu-5, ebc-1, h1993, nci-h441, a549, hct-116, u87-mg, a2780, and tov-112d, tivantinib indiscriminately inhibited cell proliferation independently of c-met gene amplification and met protein expression with an ec50 ranging from 60 to 600 nmol/l. further research showed that tivantinib promotes mitotic arrest, prevents cells from re-entering g1, and drives them to apoptosis, and induces programmed cell death regardless of the presence or absence of a functional met kinase [4].tivantinib has demonstrated antitumor activity in a wide range of human tumor cell lines and in xenograft models of human lung, colon, prostate, pancreas, and breast cancer [1] [2] [3]. female 4-week-old athymic nude (nu/nu) mice were used as experimental animals. tivantinib at a dose of 120 mg/kg significantly inhibited tumor burden in the bone of treated animals compared with the controls, starting from 14 to 21 days after cell injection. increasing doses of tivantinib decreased the number and the extent of osteolytic lesions [6].
  • in vivo

    Pharmacodynamically, the phosphorylation of c-Met in human colon xenograft tumors (HT29) is strongly inhibited by Tivantinib (ARQ 197), as assessed by a dramatic reduction of c-Met autophosphorylation 24 hours after a single oral dose of 200 mg/kg of Tivantinib. This same dosage in mice shows that tumor xenografts are exposed to sustained plasma levels of Tivantinib, consistent with the observed pharmacodynamic inhibition of c-Met phosphorylation and inhibition of proliferation of c-Met harboring cancer cell lines. A Cmax of 5.73 μg/mL (13 μM), an area under the concentration-time curve of 12.1 μg/mL h, and a t1/2 of 2.4 hours are measured. Plasma levels of Tivantinib 10 hours after dosing are determined to be 1.3 μM, >3-fold above the biochemical inhibitory constant of Tivantinib for c-Met[1].

  • target c-Met
  • References [1]. ryohei katayama, aki aoyama, takao yamori, et al. cytotoxic activity of tivantinib (arq 197) is not due solely to c-met inhibition. cancer research, 2013, 73(10): 3087-3097.
    [2]. andrew j.wagner, john m. goldberg, steven g. dubois, et al. tivantinib (arq 197), a selective inhibitor of met, in patients with microphthalmia transcription factor–associated tumors. cancer, 2012: 5894-5902.
    [3]. n. yamamoto, h. murakami, t. nishina, et al. the effect of cyp2c19 polymorphism on the safety, tolerability, and pharmacokinetics of tivantinib (arq 197): results from a phase i trial in advanced solid tumors. annals of oncology, 2013, 00: 1–7.
    [4]. cristina basilico, selma pennacchietti, elisa vigna, et al. tivantinib (arq197) displays cytotoxic activity that is independent of its ability to bind met. clin cancer res, 2013, 19(9):2381-92.
    [5]. cristina basilico, selma pennacchietti, elisa vigna, et al. tivantinib (arq197) displays cytotoxic activity that is independent of its ability to bind met. clinical cancer research, 2013, 19(9): 2381–92.
    [6]. sara previdi, giovanni abbadessa, francesca dalò, et al. breast cancer–derived bone metastasis can be effectively reduced through specific c-met inhibitor tivantinib (arq 197) and shrna c-met knockdown. mol cancer ther, 2011, 11(1):214-23.
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Spectrum
905854-02-6, 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dioneRelated Search:
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 细胞生物学试剂
  • 蛋白酪氨酸激酶
  • 小分子抑制剂，天然产物
  • ARQ197(ARQ-197,TIVANTINIB) |CAS 905854-02-6
  • C-MET酪氨酸激酶抑制剂(TIVANTINIB)
  • 化合物TIVANTINIB,10 MM DMSO 溶液
  • 替凡替尼
  • 替凡替尼 (ARQ 197)
  • RSYY(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮
  • 化合物TIVANTINIB
  • (3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉)-4-(1H-吲哚)-2,5-吡咯烷二酮
  • 905854-02-6
  • Tivantinib, 10 mM in DMSO
  • RSYY3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
  • 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione USP/EP/BP
  • ARQ197; ARQ-197; ARQ 197
  • CS-74
  • ARQ 197, Tivantinib
  • (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione Tivantinib
  • (3R,4R)-3-(2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
  • 2,5-Pyrrolidinedione,3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-, (3R,4R)-
  • (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dio
  • Tivantinib/ARQ197/ARQ-197
  • (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione
  • TIVANTINIB ARQ-197
  • (-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
  • Tivantinib
  • 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
  • 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione Tivantinib

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