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Lestaurtinib

Lestaurtinib Structure
Lestaurtinib
  • CAS No.111358-88-4
  • Chemical Name:Lestaurtinib
  • CBNumber:CB3506750
  • Molecular Formula:C26H21N3O4
  • Formula Weight:439.47
  • MOL File:111358-88-4.mol
Lestaurtinib Property
  • Melting point 215-220°C
  • Boiling point 723.0±60.0 °C(Predicted)
  • Density 1.70±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • solubility DMSO: >10mg/mL
  • form white powder
  • pka 13.37±0.40(Predicted)
  • color White or off-white
  • Stability Photosensitive
  • NCI Dictionary of Cancer Terms apalutamide; CEP-701; lestaurtinib
  • FDA UNII DO989GC5D1
  • NCI Drug Dictionary apalutamide
  • ATC code L02BB05
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • HS Code  :2934999090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P271-P261-P280
Lestaurtinib Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: C7869
  • Product name : CEP-701 hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 1MG
  • Price: ₹18380.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C7869
  • Product name : CEP-701 hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹73458.45
  • Updated: 2022/06/14
  • Buy: Buy

Lestaurtinib Chemical Properties,Usage,Production

  • Description Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2?Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3?Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4?Potent Trk inhibitor.5?Cell permeable.
  • Chemical Properties Lestaurtinib is Off-White Solid
  • Uses Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
  • Uses It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).
  • Uses CEP-701 hydrate has been used as a tyrosine kinase inhibitor:
    • to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
    • as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting?protein kinase?4 (RIPK4)
    • as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia

  • Definition ChEBI: LSM-1231 is an indolocarbazole.
  • Biological Activity Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .
  • Biochem/physiol Actions CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.
  • storage -20°C (desiccate)
  • References 1) Levis?et al. (2003),?Novel FLT3 tyrosine kinase inhibitors; Expert Opin. Investig. Drugs,?12?1951 2) Chen?et al.?(2005),?FLT3/ITD Mutation Signaling Includes Suppression of SHP-1; J. Biol. Chem.,?280?5361 3) Strock?et al. (2003),?CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth; Cancer Res.,?63?5559 4) Hexner?et al. (2008),?Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders; Blood,?111?5663 5) Ruggeri?et al. (1999),?Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models; Curr. Med. Chem.,?6?845
Lestaurtinib Preparation Products And Raw materials
Raw materials
Preparation Products
Lestaurtinib Suppliers
Global(133)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Sinoway Industrial co., ltd.
  • Tel：0592-5800732;<br/>+8613806035118
  • Email：xie@china-sinoway.com
  • Country：China
  • ProdList：987
  • Advantage：58
Lestaurtinib Spectrum
111358-88-4, LestaurtinibRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitor
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 原料药及中间体
  • 医药原料
  • C26H21N3O4
  • (5R,7S,8S)-7-羟基-7-(羟甲基)-8-甲基-5,6,7,8,13,14-六氢-15H-16-氧杂-4B,8A,14-三氮杂-5,8-甲二苯并[B,H]环八[JKL]环戊[E]-AS-茚-15-酮
  • LESTAURTINIB 来他替尼
  • 来他替尼
  • 来他替尼 CEP-701, LESTAURTINIB
  • 来他替尼、CEP-701
  • 来他替尼LESTAURTINIB,CEP-701
  • 111358-88-4
  • ritatinib
  • Lestaurtinib USP/EP/BP
  • KT5555-Lestaurtinib
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
  • LESTAURTINIB (CEP-701;KT-5555)
  • (15S,16S,18R)-16-HYDROXY-16-(HYDROXYMETHYL)-15-METHYL-28-OXA-4,14,19-TRIAZAOCTACYCLO[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]OCTACOSA-1(26),2(6),7(27),8,10,12,20,22,24-NONAEN-3-ONE
  • CS-1165
  • Lestaurtinib (KT-5555
  • SP 924
  • KT 5555
  • CEP 701
  • (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
  • A 154475.0
  • Lestaurtinib hydrate
  • KT-5555 hydrate
  • CEP-701 hydrate
  • SPM-924
  • (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
  • lestaurtinib

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