Description
Pulchinenoside B
4 is a triterpenoid glycoside that has been found in
P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B
4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B
4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the dried roots of Pulsatilla chinensis (Bge.) Regel.
References
[1] HE LUAN . Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin[J]. Phytomedicine, 2019, 56: Pages 136-146. DOI:
10.1016/j.phymed.2018.10.035[2] NAIXIN KANG . Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated from Pulsatilla chinensis in vivo[J]. Phytomedicine, 2019, 64: Article 152934. DOI:
10.1016/j.phymed.2019.152934
