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Atractylenolide-1

Atractylenolide-1 Structure
Atractylenolide-1
  • CAS No.73069-13-3
  • Chemical Name:Atractylenolide-1
  • CBNumber:CB5847745
  • Molecular Formula:C15H18O2
  • Formula Weight:230.3
  • MOL File:73069-13-3.mol
Atractylenolide-1 Property
  • Melting point 121-123 °C(Solv: ligroine (8032-32-4))
  • Boiling point 405.0±44.0 °C(Predicted)
  • Density 1.12
  • Flash point 170℃
  • storage temp. 2-8°C
  • solubility methanol: soluble1mg/mL, clear, colorless
  • form powder
  • color White
  • InChIKey ZTVSGQPHMUYCRS-SWLSCSKDSA-N
  • UNSPSC Code 41116107
  • NACRES NA.25
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Atractylenolide-1 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: A2737
  • Product name : Atractylenolide I
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹20145.33
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A2737
  • Product name : Atractylenolide I
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹67764.5
  • Updated: 2022/06/14
  • Buy: Buy

Atractylenolide-1 Chemical Properties,Usage,Production

  • Description Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.
  • Uses Atractylenolide I (Standard) is the analytical standard of Atractylenolide I. This product is intended for research and analytical applications. Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
Atractylenolide-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Atractylenolide-1 Suppliers
Global(230)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
Atractylenolide-1 Spectrum
73069-13-3, Atractylenolide-1Related Search:
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  • ATRACTYLENOLIDE I 白术内酯I/苍术内酯I |CAS 73069-13-3
  • 白术内酯 I,10 MM DMSO 溶液
  • 白术内酯I/HPLC
  • (4AS,8AS)-3,8A-二甲基-5-亚甲基-4A,5,6,7,8,8A-六氢萘并[2,3-B]呋喃-2(4H)-酮
  • 苍术内酯Ⅰ
  • 白术内酯Ⅰ对照品
  • 白术内酯Ⅰ标准品
  • 白术内酯Ⅰ(对照品)
  • ATRACTYLENOLIDEI白术内酯Ⅰ
  • 白术内酯Ⅰ
  • 苍术内酯I对照品,
  • 白术内酯 I, >99%
  • ATRACTYLENOLIDE I 白术内酯Ⅰ 标准品
  • 白术内酯Ⅰ/苍术内酯I
  • ATRACTYLENOLIDE I 白术内酯Ⅰ
  • 苍术内酯I
  • 白术内酯Ⅰ(标准品)
  • 白术内酯I(苍术内酯I)
  • 白术油
  • 白术内酯 I
  • 73069-13-3
  • Atractylenolide I, 10 mM in DMSO
  • Atractylenolide I-RM
  • (4aS,8aS)-3,8a-Dimethyl-5-methylene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one
  • Dictyolactone I
  • STAT,Atractylenolide I,Janus kinase,Inhibitor,JAK,Toll-like Receptor (TLR),inhibit
  • Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
  • Extracted oil
  • Atracylenolide I
  • Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
  • Atractylenolide I, >99%
  • Atractylenolide Ⅰ
  • (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
  • 8,9-Dehydroasterolide
  • Eudesma-4(15),7(11),8-trien-12-olide
  • 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one

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