Toxicity
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HigenaMine Hydrochloride

Toxicity
HigenaMine Hydrochloride Structure
HigenaMine Hydrochloride
  • CAS No.11041-94-4
  • Chemical Name:HigenaMine Hydrochloride
  • CBNumber:CB01178445
  • Molecular Formula:C16H18ClNO3
  • Formula Weight:307.77
  • MOL File:11041-94-4.mol
HigenaMine Hydrochloride Property
  • storage temp. 4°C, protect from light
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • color Pale Beige to Pale Brown
  • Stability Hygroscopic
  • FDA UNII PQ432PID6E
Safety
  • Toxicity :mouse,LD50,intravenous,17250ug/kg (17.25mg/kg),Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 489, 1982.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H319-H410
  • Precautionary statements P264-P273-P280-P337+P313-P391-P501
HigenaMine Hydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2313
  • Product name : Higenamine hydrochloride
  • Purity: ≥95% (HPLC)
  • Packaging: 5MG
  • Price: ₹7804.83
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2313
  • Product name : Higenamine hydrochloride
  • Purity: ≥95% (HPLC)
  • Packaging: 25MG
  • Price: ₹31587.35
  • Updated: 2022/06/14
  • Buy: Buy

HigenaMine Hydrochloride Chemical Properties,Usage,Production

  • Toxicity The safety of orally administered higenamine hydrochloride in humans is unknown. During a study of acute toxicity, mice were orally administered the compound at a dose of 2 g per kg of bodyweight. No mice died during the study.In human trials of intravenous higenamine, subjects who received higenamine reported shortness of breath, racing heart, dizziness, headaches, chest tightness.
  • Description Higenamine is a chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others. HigenaMine Hydrochloride is the hydrochloride form of higenamine.
  • Uses Higenamine HCl (norcoclaurine) is a plant-based alkaloid widely used as nutritional supplement in food and beverage industries.
  • in vivo

    Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2].
    Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4].
    Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6].

    Animal Model:Spontaneous osteoporosis SAMP6 mice model[6]
    Dosage:10 mg/kg, 20 mg/kg
    Administration:Intraperitoneal injection (i.p.);Once daily for 60 days
    Result:Significantly increased the expression of P1NP and OCN (P1NP and OCN are markers of bone formation).
  • IC 50 β adrenergic receptor; ASK1
HigenaMine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
HigenaMine Hydrochloride Suppliers
Global(241)Suppliers
  • Supplier：
    Hi-Tech Chemistry Corp
  • Tel：0519-86626038
  • Email：yuhh@hitechem.com
  • Country：CHINA
  • ProdList：810
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    Accela ChemBio Inc.
  • Tel：+1-858-6993322
  • Email：info@accelachem.com
  • Country：United States
  • ProdList：19825
  • Advantage：58
HigenaMine Hydrochloride Spectrum
11041-94-4, HigenaMine HydrochlorideRelated Search:
  • 11041-94-4
  • 生物碱类
  • 有机原料
  • 抑制剂
  • 化学试剂
  • 药靶配体
  • 生物医药-医药原料
  • 其他中间体
  • 化工原料
  • 有机中间体
  • 医药化工类
  • 标准品，对照品
  • 标准品 -中药标准品
  • 对照品
  • 对照品-中药对照品
  • 医药原料
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  • 对照品
  • 对照品,标准品
  • 中间体
  • 医药中间体
  • 植提
  • 生物医药
  • 植物提取物
  • 标准品
  • 盐酸去甲乌头碱
  • 保健品添加剂
  • 盐酸去甲乌头碱,10 MM DMSO 溶液
  • HIGENAMINE HCL|||DEMETHYLCOCLAURINE HYDROCHLORIDE|||盐酸去甲乌头碱|||NORCOCLAURINE HCL|||(+-)-DEMETHYLCOCLAURINE HYDROCHLORIDE|||HIGENAMINEU00A0HYDROCHLORIDE
  • 1-(4-羟基苄基)-1,2,3,4-四氢异喹啉-6,7-二醇盐酸盐
  • 1-(4-HYDROXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6,8-DIOL HYDROCHLORIDE
  • 盐酸去甲乌药碱对照品
  • 盐酸去甲乌药碱标准品
  • 盐酸去甲乌药
  • 去甲乌药碱盐酸盐(标准品)
  • 1-(4-羟基苄基)-6,7-二羟基-1,2,3,4-四氢异喹啉盐酸盐
  • 消旋去甲基衡州乌药碱盐酸盐
  • 去甲乌药碱盐酸盐
  • 盐酸去甲乌头碱
  • 盐酸去甲乌药碱
  • 11041-94-4
  • (+/-)-Higenamine HCl - synthetic
  • (+/-)-Higenamine HCl - natural
  • (+/-)-Higenamine HCl - synthetic - Bio-X ?
  • Higenamine hydrochloride, 10 mM in DMSO
  • Higenamine hydrochloride-RM
  • Higenamine HCl|||Demethylcoclaurine hydrochloride|||norcoclaurine HCl|||(+-)-Demethylcoclaurine hydrochloride|||Higenamineu00A0Hydrochloride
  • (+/-)-Higenamine HCl
  • Demethyl Trelagllptin
  • 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-Isoquinolinediol hydrochloride (1:1)
  • 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline
  • Dacacine base acid and alkali salt
  • AI3-01335
  • AI301335
  • AI3 01335
  • 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
  • _x000D_6，7-Dihydroxy-1-(4-Hydroxybenzyl)-1，2，3，4-tetrahydroisoquinoline Hydrochloride
  • (+/-)-Higenamine HCl - synthetic

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