Synthesis
The general procedure for the synthesis of monoethyl succinate chloride from monoethyl succinate: monoethyl succinate (116.8 g, 0.8 mol), dichloromethane (300 mL) and thionyl chloride (104 g, 0.88 mol) were added to a reaction flask, N,N-dimethylformamide (0.8 g) was added under nitrogen protection, and heated and stirred by refluxing for 5 hours at 38°C. The reaction was completed with a solution of dichloromethane (124 g, 0.88 mol). Upon completion of the reaction, a dichloromethane solution of monoethylsuccinic acid chloride (124 g, yield: 95%) was obtained.
References
[1] Heterocycles, 2001, vol. 55, # 8, p. 1487 - 1498
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 7, p. 1528 - 1536
[3] Patent: CN104326922, 2016, B. Location in patent: Paragraph 0038; 0040
[4] Journal of the American Chemical Society, 1991, vol. 113, # 6, p. 2071 - 2092
[5] Journal of Organic Chemistry, 1996, vol. 61, # 14, p. 4848 - 4852
