Description
Butyl chloride is a highly flammable, clear,colorless liquid. Molecular weight = 92.6 (n- and sec-isomers); Boiling point = 77℃; 69℃ (sec-isomer); Specificgravity (H2O:1) = 0.89; Freezing/Melting point =-123℃; Flash point = 9℃; - 10℃ (sec-isomer);Relative vapor density (air =1) = 3.2 (n- and sec-isomers);Vapor pressure = 81 mmHg at 20℃; Autoignitiontemperature = 240℃. Explosive limits: LEL = 1.8%;UEL = 10.1%. Insoluble in water. Hazard Identification(based on NFPA-704 M Rating System): Health 2,Flammability 3, Reactivity 0; (sec-) Health 2, Flammability4, Reactivity 0. Practically insoluble in water;solubility = 0.7% at 12℃.
Chemical Properties
1-Chlorobutane is a highly flammable, clear, colorless liquid at standard temperature and pressure. The density is 0.886 g/cm3, which is lower than that of water. It does not react with water, is classified as highly flammable, but it is neither an oxidizer nor an explosive. However, vapors can form explosive mixtures with air. The substance self-ignites at 245℃.
Uses
1-Chlorobutane may be used in the synthesis of ionic liquids, 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]
+[HSO
4]
-) and 1-butyl-3-methylimidazolium dihydrogen phosphate ([Bmim]
+[H
2PO
4]
-).
Uses
1-Chlorobutane is used as intermediates and solvents. It is used for HPLC, spectrophotometry and environmental testing. It is used as alkylating reagent in organic and organometallic compound synthesis. It is also employed as an antihelmintic in veterinary medicine.
Uses
1-Chlorobutane is used as an intermediate for the production of other chemicals in the chemical industry.
1-chlorobutane is a common extraction solvent in the forensic toxicology arena. A benefit of 1-chlorobutane is that it is less dense than water and therefore settles above the aqueous layer.
As butylating agent in organic synthesis, e.g., in the manufacture of butyl cellulose.
1-chlorobutane will be halogenated to produce dichlorobutane using sulfuryl chloride via a free-radical chain reaction mechanism.
Preparation
1-Chlorobutane is obtained by esterification of n-butanol with hydrogen chloride or hydrochloric acid at 100℃ either without a catalyst or utilizing the accelerating effect of zinc chloride, tripentylamine hydrochloride, or phosphorus pentachloride. n-Butyl chloride is also obtained, along with 2-chlorobutane, by the chlorination of butane over aluminum oxide at 200℃.
General Description
A water white liquid with a sharp odor. Flash point 20°F. Boiling point 77-78°C (173°F). Density 7.5 lb / gal. Slightly soluble in water. Vapors are heavier than air. Used in the manufacture of a variety of organic chemicals.
Air & Water Reactions
Highly flammable. May react with atmospheric moisture over prolonged periods of exposure. Slightly soluble in water.
Reactivity Profile
1-Chlorobutane is incompatible with oxidizing agents and strong bases. Reacts with aluminum powder, liquid oxygen, potassium and sodium . Emits phosgene gas when heated to decomposition,. Reacts with aluminum and magnesium. May be sensitive to heat.
Hazard
Toxic on prolonged inhalation. Flammable,
dangerous fire risk.
Health Hazard
1-Chlorobutane has a low acute toxicity by oral exposure. mildly irritating to the skin and eyes, liquid may cause rash due to removal of skin oils. Ingestion or skin absorbtion may cause intestinal upset, cramping, and central nervous system depression. 1- Chlorobutane is also not considered mutagenic, carcinogenic or toxic to reproduction.
Fire Hazard
Special Hazards of Combustion Products: May produce phosgene gas in fire
Flammability and Explosibility
Flammable
Safety Profile
Moderately toxic by
ingestion. Mutation data reported. See
CHLORINATED HYDROCARBONS,
ALIPHATIC. Skin and eye irritant.
Dangerous fire hazard when exposed to heat
or flame. Moderately explosive when exposed to flame. When heated to
decomposition it emits hghly toxic fumes of
phosgene and Cl-. To fight fire, use foam,
COa, dry chemical. Incompatible with
oxidizing materials
Potential Exposure
Butyl chloride is used as a solvent; as
a medicine to control worms, and to make other chemicals
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If 1-Chlorobutane contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. stopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit
storage
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.1-Chlorobutane is incompatible with oxidizers (such as perchlorates, peroxides, permanganates, chlorates and nitrates).Store in tightly closed containers in a cool, well-ventilatedarea. Sources of ignition, such as smoking and open flames,are prohibited where Butyl chloride is handled, used, orstored. Metal containers involving the transfer of 5 gallonsor more of 1-Chlorobutane should be grounded and bonded.Drums must be equipped with self-closing valves, pressurevacuum bungs, and flame arresters. Use only nonsparkingtools and equipment, especially when opening and closingcontainers of 1-Chlorobutane.
Shipping
UN1127 Chlorobutanes require, Hazard Class: 3;
Labels: 3—Flammable liquid
Purification Methods
Shake repeatedly with concentrated H2SO4 (until no more color develops in acid), then wash with water, aqueous NaHCO3 or Na2CO3, and more water. Dry with CaCl2 or MgSO4 (then with P2O5, if necessary), decant and fractionate. Alternatively, continue to pass oxygen for about three times until the outlet gas first develops color on starch iodide paper. After washing with NaHCO3 solution to hydrolyze the ozonide and remove the organic acid produced, the 1-chlorobutane liquid is dried and distilled [Chien & Willard J Am Chem Soc 75 6160 1953]. [Beilstein 1 IV 246. ]
Incompatibilities
Vapor may form explosive mixture with
air. May accumulate static electrical charges, and may
cause ignition of its vapors. Water contact slowly forms
hydrochloric acid. Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, alkaline earth, and alkali
metals; finely divided metal. Attacks metals in presence of
moisture. Attacks some plastics, rubber, or coatings
Toxics Screening Level
The initial threshold screening level (ITSL) for n-butyl chloride is 1500 μg/m3 based on an annual averaging time
Waste Disposal
Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal,
state, and local environmental regulations must be
observed.
