Chemical Properties
Light yellow crystalline powder, easily soluble in chloroform and ethyl acetate, soluble in hot ethanol and hot benzene, insoluble in water and petroleum ether, derived from the dry near-ripe or ripe fruit of Piper nigrum L.
Biological Activity
Tetrahydropiperine is a cyclohexyl analog of piperine, the first natural arylvaleramide from Piper longum. Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/aryl hydrocarbon hydroxylase (AHH; IC50=23 μM).