Originator
Versacort,Angelini,Italy,1978
Manufacturing Process
Hydrocortisone (25 g) and bendazac chloride (21 g) are suspended in
anhydrous dioxane (250 ml). Pyridine (6 ml) is added and the solution is kept
under stirring for 2 hours at room temperature. Pyridine hydrochloride which
separates is filtered and the clear dioxane solution is added, under strong
stirring, to a solution of sodium bicarbonate (20 g) in distilled water (2,500
ml). The colorless precipitate which is formed is filtered, washed with water
and dried on a porous plate. The substance crystallizes from ethanol. Needles.
MP 174°-176°C. Yield: 75%.