Versacort,Angelini,Italy,1978
Hydrocortisone (25 g) and bendazac chloride (21 g) are suspended in
anhydrous dioxane (250 ml). Pyridine (6 ml) is added and the solution is kept
under stirring for 2 hours at room temperature. Pyridine hydrochloride which
separates is filtered and the clear dioxane solution is added, under strong
stirring, to a solution of sodium bicarbonate (20 g) in distilled water (2,500
ml). The colorless precipitate which is formed is filtered, washed with water
and dried on a porous plate. The substance crystallizes from ethanol. Needles.
MP 174°-176°C. Yield: 75%.