Uses
Proquazone is a non-steroidal anti-inflammatory drug.
Definition
ChEBI: Proquazone is a member of pyrimidines.
brand name
Arthrex (Novartis), Biarison (Swiss-Pharma,
Egypt; Biochemie, Austria; ICN Alkaloida,
Hungary; Sandoz, Finland, Turkey).
Clinical Use
Proquazone has been used successfully to
treat rheumatoid polyarthritis. At 900 mg/d it
is comparable in effect to 150 mg/d of indomethacin. Gastrointestinal disturbances are
the principal adverse effects observed with its
use.
Synthesis
Synthesis: proquazone is prepared by the
alkylation of 2-amino-4-methylbenzophenone
with 2-iodopropane in the presence of
sodium carbonate to give 4-methyl-2-[(1-
methylethyl)amino]benzophenone, which is
condensed with urethane in the presence of
zinc chloride at 190 ?C.
