4-Methylhistamine dihydrochloride

Description

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

Uses

Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.

Biological Activity

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

storage

Desiccate at RT

References

[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.