Description
Acetyl-CoA (75520-41-1) is an essential cofactor for cellular metabolism, being an ‘activated acetate’ that shuttles its moieties back and forth during anabolic, catabolic, and metabolic processes involving fundamental molecules: fatty acids, amino acids, glucose, and ATP.1 In the laboratory, it can be used as a substrate in chloramphenicol acetyltransferase (CAT) transcription reporter assays2 or in histone acetyltransferase (HAT) assays in epigenetics research3.
Chemical Properties
White amorphous powder
Uses
Acetyl Coenzyme?A Lithium Salt is an important molecule in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to acyl carrier proteins and formyltetrahydrofolate dehydrogenase.
References
Wolfe (2005), The acetate switch; Mol. Biol. Rev. 69 12
Gorman et al. (1982), Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells; Mol. Cell Biol. 2 1044
Kim et al. (2000), A continuous, nonradioactive assay for histone acetyltransferases; Anal. Biochem. 280 308
