Chemical Properties
Beige crystals
Uses
A cofactor in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to proteins such as acyl carrier protein and formyltetrahydrofol
ate dehydrogenase
Uses
Coenzyme A trilithium salt has been used:
- in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
- as a cofactor in JNADH and JNADPH production assay
- in the labeling of Alexa647 (AF647) probe
General Description
Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.
Biochem/physiol Actions
Coenzyme A is a ubiquitous cofactor, synthesized from pantothenic acid through a ATP dependent reaction. It plays a vital role in tricarboxylic acid cycle, metabolism of short- and long-chain fatty acids. In addition, it also aids in synthesis of phospholipids and cell growth.
