Description
(–)-Perillyl alcohol is a monoterpene alcohol that has been found in lavender essential oil and has diverse biological activities. It reduces production of hydroperoxidienes and thiobarbituric acid reactive substances (TBARS)
in vitro in a concentration-dependent manner. (–)-Perillyl alcohol inhibits PANC-1 pancreatic carcinoma cell and H-Ras-transformed fibroblast growth when used at a concentration of 1 mM. It also inhibits the growth of
P. aeruginosa,
E. coli,
S. aureus, and
C. albicans (MICs = 480-2,900 ppm).
Uses
(-)-Perillyl Alcohol is a monoterpene that induces apoptosis in colon tumor cells. Also, it is used in preparation of terpene-vanilloid conjugates as anti-inflammatory agents.
Definition
ChEBI: (S)-(-)-perillyl alcohol is a perillyl alcohol in which the chiral centre has S configuration. It is an enantiomer of a (R)-(+)-perillyl alcohol.
General Description
(
S)-(-)-Perillyl alcohol is a monoterpenoid compound found in the essential oils of cherries, lavender and spearmint. It shows potent anticancer activity.
References
[1] CLARISSA GERHUSER. Mechanism-based in vitro screening of potential cancer chemopreventive agents[J]. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 2003, 523: Pages 163-172. DOI:
10.1016/s0027-5107(02)00332-9[2] GIUSEPPE RUBERTO Maria T B. Antioxidant activity of selected essential oil components in two lipid model systems[J]. Food Chemistry, 2000, 69 2: Pages 167-174. DOI:
10.1016/s0308-8146(99)00247-2[3] J KARLSON. Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.[J]. Anti-Cancer Drugs, 1996, 7 4: 422-429. DOI:
10.1097/00001813-199606000-00008[4] SHANE G. GRIFFIN. The role of structure and molecular properties of terpenoids in determining their antimicrobial activity[J]. Flavour and Fragrance Journal, 1999, 14 5: 322-332. DOI:
10.1002/(sici)1099-1026(199909/10)14:5<322::aid-ffj837>3.0.co;2-4
