Description
ML-192 is an antagonist of GPR55 (IC
50 = 702 nM). It is selective for GPR55 over the cannabinoid (CB) receptors CB
1 and CB
2, as well as GPR35 (IC
50s = >32 μM).
Uses
ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1].
Definition
ChEBI: 2-furanyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone is a N-arylpiperazine.
References
[1] Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69. DOI:
10.1021/bi4008885
