Application
(R)-(+)-2-amino-3-methyl-1,1-diphenyl-1-butanol can be used as a pharmaceutical synthesis intermediate. It can be prepared from (D)-valine as a reactant or from Boc-D-valine methyl ester. It is mainly used in laboratory research and development and chemical production processes.
Synthesis
1. D-Valine reacts with SOCl/MeOH to give D-valine methyl ester.
2. D-Valine methyl ester reacts with a Grignard reagent prepared from bromobenzene to yield (R)-(+)-2-amino-3-methyl-1,1-diphenyl-1-butanol.