Description
SIA Crosslinker is a non-cleavable, water-soluble crosslinker containig an NHS ester and an iodine group. The NHS ester is reactive toward amines while the iodine reacts with thiol groups.
Chemical Properties
White Solid
Uses
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms
Uses
forms water soluble carboxylate derivatives
Uses
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
Spacer Arm: 1.5 Angstroms
Biological Activity
SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
