Chemical Properties
white to beige or light tan adhering crystals or
Uses
Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.
Uses
Acetylating agent for capping unreacted amino groups in peptide synthesis.
Uses
It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.
Definition
ChEBI: N-acetylimidazole is a N-acylimidazole.
General Description
Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.
Purification Methods
It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.]
