TCO-PEG12-NHS Ester
- Product NameTCO-PEG12-NHS Ester
- CAS2185016-39-9
- CBNumberCB93345118
- MFC40H70N2O18
- MW866.99
- MDL NumberMFCD30536161
- MOL File2185016-39-9.mol
Chemical Properties
| Density | 1.20±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 11.95±0.46(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
TCO-PEG12-NHS Ester Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| BroadPharm BP-24123 | 50mg | $800 | TCO-PEG12-NHSester 95% |
Buy |
TCO-PEG12-NHS Ester Chemical Properties,Usage,Production
Description
TCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.Biological Activity
TCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
