ChemicalBook CAS DataBase List 2185016-39-9

2185016-39-9

Name	TCO-PEG12-NHS Ester
CAS	2185016-39-9
Molecular Formula	C40H70N2O18
MDL Number	MFCD30536161
Molecular Weight	866.99
MOL File	2185016-39-9.mol

Chemical Properties

density	1.20±0.1 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
form	Liquid
pka	11.95±0.46(Predicted)
color	Colorless to light yellow

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Hazard Information

Description

TCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

Biological Activity

TCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Supplier

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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Zhengzhou Akem Chemical Co., Ltd

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Affinity（Wuhan）Ltd.

Telephone 15841022315

Websitehttps://precisepeg.com

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Websitehttp://www.chemextension.com

shanghai Yanfeng biochemical technology Co.,LTD

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Shanghai Zhiyun Biotechnology Co., Ltd

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Website

Jilin Chinese Academy of Sciences-yanshen Technology

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TargetMol Chemicals Inc.

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Henan Mengtai Pharmaceutical Technology Co., Ltd

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Shaanxi Xingbei Aike Biotechnology Co., Ltd

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NOVOCOM

Telephone0512-67298826 18362736473

Websitehttps://www.nvcbiotech.com

Affinity Linkers Ltd.

Telephone15841022315 15841022315

Websitehttps://precisepeg.com/

Xian confluore Biological Technology Co., Ltd.

Telephone+86-15680926068

Websitehttp://www.confluore.com/

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