ChemicalBook CAS DataBase List 2185016-39-9

2185016-39-9

Name	TCO-PEG12-NHS Ester
CAS	2185016-39-9
Molecular Formula	C40H70N2O18
MDL Number	MFCD30536161
Molecular Weight	866.99
MOL File	2185016-39-9.mol

Chemical Properties

density	1.20±0.1 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
form	Liquid
pka	11.95±0.46(Predicted)
color	Colorless to light yellow

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Hazard Information

Description

TCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

Biological Activity

TCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Supplier

Beijing Jin Ming Biotechnology Co., Ltd.

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Websitehttp://www.jm-bio.com/

Xi'an Confluore Biological Technology Co., Ltd.

Telephone+86-156-80926068 +86-15680926068

Websitehttp://www.confluore.cn/

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Shanghai Haohong Pharmaceutical Co., Ltd.

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Websitehttps://www.leyan.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85563444 18351873721

Websitehttp://www.synzest.com

Zhengzhou Akem Chemical Co., Ltd

Telephone 13303867194

Websitehttp://acmechem.cn/

Affinity（Wuhan）Ltd.

Telephone 15841022315

Websitehttps://precisepeg.com

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Telephone0431-80514535 19917294565

Websitehttp://www.chemextension.com

Shanghai Easy CDMO Co.,Ltd

Telephone021-61734564

Website

Shanghai Zhiyun Biotechnology Co., Ltd

Telephone 13119135307

Website

Jilin Chinese Academy of Sciences-yanshen Technology

Telephone 18143011203

Websitehttp://www.chemextension.com/

Xian confluore Biological Technology Co., Ltd.

Telephone+86-15680926068 +86-15680926068

Websitehttp://www.confluore.com/

Jilin Chinese Academy of Sciences-yanshen Technology

Telephone +undefined18143011203

Websitehttp://www.chemextension.com/

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Cleavable

PEGs