TCO-PEG12-NHS Ester

Product NameTCO-PEG12-NHS Ester
CAS2185016-39-9
MFC40H70N2O18
MW866.99
EINECS
MOL File2185016-39-9.mol

Chemical Properties

Density	1.20±0.1 g/cm3(Predicted)
solubility	Soluble in DMSO, DCM, DMF
pka	11.95±0.46(Predicted)
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Description

TCO-PEG12-NHS Ester is a water soluble PEG linker containing a TCO moiety and a NHS ester. PEG12 linear arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety.

Biological Activity

TCO-PEG12-NHS ester is a PROTAC bridge and belongs to the PEG class.It can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

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Cleavable

PEGs