Physical properties
mp 62–65°C; bp 87–90°C/40 mmHg.
Uses
O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine)is used to induce the cleavage, during solid supported synthesis of hydroxamic acids. It also finds it uses as a chemical additive and an intermediate.
Uses
O-(
tert-Butyldimethylsilyl)hydroxylamine (
tert-butyldimethylsilyl-
O-hydroxylamine) may be used to induce the cleavage, during solid supported synthesis of hydroxamic acids.
Preparation
the reagents are most conveniently prepared
by treatment of hydroxylamine hydrochloride with
ethylenediamine in dichloromethane, followed by the appropriate
chlorosilane.A two-step procedure using ammonia in
place of ethylenediamine has also been reported.
