Chemical Properties
clear colorless liquid
Uses
The product can be used as a reagent for peptide synthesis.
Uses
Tetraethyl Pyrophosphite is used as a reagent in the preparation of peptides and in the phosphonylation of carbonyl compounds.
Application
Tetraethyl pyrophosphite can be used in peptide synthesis; phosphonylation of ketones, aldehydes, and perfluoroalkyl iodides.
Preparation
The most convenient method involves the reaction of diethyl phosphite with diethyl phosphorochloridite. Diethyl phosphorochloridite (223 g) is added rapidly to a solution of diethyl phosphite (138 g) and triethylamine (101 g) in benzene (200 ml). The mixture is filtered and the benzene removed by distillation at reduced pressure. The product is isolated by further distillation at reduced pressure (79-81 °C/0.15 mmHg) in 41% yield.
