Description In vitro In vivo
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OMecaMtiv Mecarbil

Description In vitro In vivo
OMecaMtiv Mecarbil Structure
OMecaMtiv Mecarbil
  • CAS No.873697-71-3
  • Chemical Name:OMecaMtiv Mecarbil
  • CBNumber:CB92561487
  • Molecular Formula:C20H24FN5O3
  • Formula Weight:401.43
  • MOL File:873697-71-3.mol
OMecaMtiv Mecarbil Property
Hazard and Precautionary Statements (GHS)
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  • Signal word
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OMecaMtiv Mecarbil Price More Price(27)
  • Brand: Cayman Chemical
  • Product number: 21074
  • Product name : CK-1827452
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $29
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 21074
  • Product name : CK-1827452
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $138
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: C544000
  • Product name : CK1827452
  • Purity: 
  • Packaging: 10mg
  • Price: $250
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: C544000
  • Product name : CK1827452
  • Purity: 
  • Packaging: 50mg
  • Price: $820
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: ApexBio Technology
  • Product number: A8349
  • Product name : Omecamtivmecarbil
  • Purity: 
  • Packaging: 50mg
  • Price: $679
  • Updated: 2021/12/16
  • Buy: Buy

OMecaMtiv Mecarbil Chemical Properties,Usage,Production

  • Description Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
  • In vitro In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [
  • In vivo Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
  • Uses CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
  • Uses CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
OMecaMtiv Mecarbil Preparation Products And Raw materials
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873697-71-3, OMecaMtiv MecarbilRelated Search:
  • 1-Piperazinecarboxylic acid,4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-, methyl ester
  • OMecaMtiv Mecarbil
  • OMecaMtiv Mecarbil (CK-1827452)
  • CK1827452
  • CK-1827452
  • CK-1827452 (OMecaMtiv Mecarbil)
  • CK 1827452O
  • mecamtiv mecarbil
  • Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate
  • methyl 4-(2-fluoro-3-(3-(6-methylpyridin-3-yl)ureido)benzyl)piperazine-1-carboxylate
  • Methyl 4-[[2-fluoro-3-[N'-(6-methylpyridin-3-yl)ureido]phenyl]methyl]piperazine-1-carboxylate Omecamtiv mecarbil(CK1827452)
  • methyl 4-[(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}phenyl)methyl] piperazine-1-carboxylate
  • OMECAMTIV MECARBIL (CK-1827452);CK1827452
  • CK 1827452 - Omecamtiv Mecarbil | CK-452
  • CK-1827452; CK1827452;CK 1827452
  • CS-827
  • CK1827452, >98%
  • Omecamtiv mecarbil?, >98%
  • OMecaMtiv Mecarbil USP/EP/BP
  • 873697-71-3
  • C20H24FN5O3
  • Inhibitors