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GSK-2126458

GSK-2126458 Structure
GSK-2126458
  • CAS No.1086062-66-9
  • Chemical Name:GSK-2126458
  • CBNumber:CB92505205
  • Molecular Formula:C25H17F2N5O3S
  • Formula Weight:505.5
  • MOL File:1086062-66-9.mol
GSK-2126458 Property
  • Melting point: :187-189℃
  • Boiling point: :715.6±70.0 °C(Predicted)
  • Density  :1.45
  • pka :6.23±0.40(Predicted)
  • FDA UNII :1X8F5A3NA0
Safety
  • HS Code  :29350090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
GSK-2126458 Price More Price(33)
  • Brand: Cayman Chemical
  • Product number: 17377
  • Product name : GSK2126458
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $39
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 17377
  • Product name : GSK2126458
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $176
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Tocris
  • Product number: 6792
  • Product name : Omipalisib
  • Purity: ≥98%(HPLC)
  • Packaging: 50
  • Price: $459
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: G797500
  • Product name : GSK2126458
  • Purity: 
  • Packaging: 100mg
  • Price: $460
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Axon Medchem
  • Product number: Axon1596
  • Product name : GSK2126458-Omipalisib
  • Purity: 99%
  • Packaging: 2 x 25 mg
  • Price: $506
  • Updated: 2021/12/16
  • Buy: Buy

GSK-2126458 Chemical Properties,Usage,Production

  • Description GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 (Item No. 18092) to suppress the growth of SNU-1040 colorectal cancer cells.
  • Uses A highly potent inhibitor of PI3K and the mammalian target of Rapamycin.
GSK-2126458 Preparation Products And Raw materials
Raw materials
Preparation Products
Global(141)Suppliers
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1086062-66-9, GSK-2126458Related Search:
  • GSK2126458
  • GSK-2126458
  • GSK2126458; GSK-2126458
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • GSK2126458 (HYR-582)
  • CS-55
  • Omipalisib GSK2126458
  • HYR-582
  • GSK212
  • 2,4-Difluoro-N-[2-Methoxy-5-[4-(pyridazin-4-yl)quinolin-6-yl]pyridin-3-yl]benzenesulfonaMide
  • OMipalisib
  • GSK458
  • Omipalisib (GSK2126458, GSK458)
  • 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide GSK2126458(GSK458)
  • GSK 2126458 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
  • 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
  • GSK2126458 (GSK458)
  • GSK2126458, >=98%
  • GSK2126458(Omipalisib)
  • GSK2126458 (GSK458);GSK458;GSK-212; GSK-2126458
  • Omipalisib, 98%, a highly selective and potent inhibitor of PI3K
  • Omipalisib GSK458
  • Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
  • GSK-2126458 USP/EP/BP
  • 1086062-66-9
  • C25H17F2N5O3S
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • PI3K/Akt/mTOR
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds