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2,4,7-TRINITRO-9-FLUORENONE

2,4,7-TRINITRO-9-FLUORENONE Structure
2,4,7-TRINITRO-9-FLUORENONE
  • CAS No.129-79-3
  • Chemical Name:2,4,7-TRINITRO-9-FLUORENONE
  • CBNumber:CB9210251
  • Molecular Formula:C13H5N3O7
  • Formula Weight:315.19
  • MOL File:129-79-3.mol
2,4,7-TRINITRO-9-FLUORENONE Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P305+P351+P338
2,4,7-TRINITRO-9-FLUORENONE Price More Price(2)
  • Brand: Sigma-Aldrich
  • Product number: T7539
  • Product name : Tumor Necrosis Factor-α from mouse
  • Purity: TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
  • Packaging: 10 μg
  • Price: $240
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: T7539
  • Product name : Tumor Necrosis Factor-α from mouse
  • Purity: TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture
  • Packaging: 50 μg
  • Price: $636
  • Updated: 2021/12/16
  • Buy: Buy

2,4,7-TRINITRO-9-FLUORENONE Chemical Properties,Usage,Production

  • Uses
    Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:
    • to activate MS1 endothelium cells
    • to induce lipolysis in adipocytes
    • to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation
  • General Description Pale yellow needles (from acetic acid or benzene) or yellow powder.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction.
  • Hazard Suspected carcinogen. Mildly toxic by ingestion. A skin and eye irritant.
  • Fire Hazard Literature sources indicate that 2,4,7-TRINITRO-9-FLUORENONE is flammable.
  • Biochem/physiol Actions The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
  • Safety Profile Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Human mutation data reported. A skin and eye irritant. When heated to decomposition it emits hghly toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and KETONES.
  • Purification Methods Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.]
2,4,7-TRINITRO-9-FLUORENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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129-79-3, 2,4,7-TRINITRO-9-FLUORENONERelated Search:
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  • Recombinant Human TNF Protein, His Tag
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  • Recombinant Human TNF-alpha Protein, His Tag
  • 129-79-3
  • C13H5N3O7
  • Fluorenes, Flurenones