Chemical Properties
White or almost white, crystalline powder.
Uses
Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine hydrochloride has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.
Uses
Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.
brand name
Dopacard (Fisons).
Clinical Use
Inotropic support in exacerbations of heart failure and
heart failure associated with cardiac surgery
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: risk of ventricular arrhythmias with
isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Beta-blockers: risk of severe hypertension
Dopaminergics: avoid with rasagiline.
Sympathomimetics: effects of adrennoradrenaline possibly enhanced.
Metabolism
Dopexamine is rapidly eliminated from blood with a halflife of approximately 6-7 minutes in healthy volunteers
and around 11 minutes in patients with cardiac failure.
Subsequent elimination of the metabolites is by urinary
and biliary excretion.
