Preparation
Add 500g of acetal A to a reaction vessel, add 500g of 5% phosphoric acid, heat to 60℃, start stirring, and stir for 6 hours. Stop the reaction when the acetal content is less than 1%. After the reaction is complete, wash the material with a 5% sodium hydroxide solution until the aqueous phase is weakly alkaline. Then, distill the washed crude product to obtain 410g of 2-ISOBUTYL-4-HYDROXY-4-METHYLTETRAHYDROPYRAN with a GC content of 97% and a yield of 82%.
Application
2-ISOBUTYL-4-HYDROXY-4-METHYLTETRAHYDROPYRAN can be used in almost all types of perfumes, producing an elegant, diffused floral scent without altering the original fragrance characteristics. It has a long-lasting fragrance and is stable in perfumes, face creams, talcum powders, and other daily chemical products, making it an excellent fragrance raw material.
Chemical Properties
2-Isobutyl-4-methyltetrahydro-2H-pyran-4-ol is a colorless to pale yellow
liquid with a fresh, soft, and natural floral odor.
Cyclocondensation of 3-methyl-3-buten-l-ol with 3-methylbutanal on silica gel
and alumina in the absence of solvents is proposed for synthesis.The material
consists of a cis/trans-isomer mixture. The proportion of the more valuable
cis-isomer can be increased by using dilute sulfuric acid as catalyst.
Flammability and Explosibility
Non flammable
Trade name
Florol® (Firmenich), Florosa (Givaudan), Florosol (Innospec),
Pyranol (BASF).
