Worenine

Description

This quaternary alkaloid is present in Cop tis japonica and has been isolated as the tetrahydro base, colourless prisms from EtOH with m.p. 2l2-3°C, oxidized by iodine in EtOH to worenine iodide. The latter forms yellow crystals from which the corresponding chloride may be obtained in the form of orange-yellow prisms, m.p. 295°C (dec.).

Chemical Properties

Red crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Coptis chinensis.

Uses

Worenine is used in the a flurophore switched probe which aids in correction of an abasic site (AP site) caused by the removal of a damaged base in DNA

Definition

ChEBI: Worenine is an alkaloid.

References

Kitasato., J. Pharm. Soc., Japan, No. 542, 48 (1927) Kitasato., Acta Phytochimica, 3,210 (1927)