Synthesis
o-Toluene ( 1 mmol) was dissolved in 3 mL of ethanol and 1.02 was added to the resulting mixture.
mmol of N-bromosuccinimide purified by recrystallization. The resulting mixture was stirred at room temperature for 1
The progress of the reaction was monitored by passing a TLC spot plate to ensure that all the ingredients were fully reacted, and then the solvent ethanol was removed under reduced pressure. Then 10 mL of ethyl acetate and 10 m were added to the reaction system.
L distilled water, the mixture was transferred to a partition funnel to separate the organic ( ethyl acetate ) fraction, and then ethyl acetate ( 2 7 m ) was used to extract the water.
L) to extract the aqueous layer. All the ethyl acetate extracts were combined and dried over anhydrous Mg SO4, the organic solvent was spun dry, and the crude product was purified by column chromatographic separation to give the target product molecule 4-bromo-2-methylphenol.
