Synthesis
To a stirred solution of appropriate organoboronic acids (0.5 mmol, 1.0 equiv.) and Et
3N(1.0 mmol, 2.0 equiv.) in CH
3CN(acetonitrile: 3 mL, H2O: 11μL, 0.6mmol, 1.2 equiv.), DAIB (0.75 mmol, 1.5 equiv.),dissolved in acetonitrile (2mL) was added drop wise at room temperature and the mixture was allowed to stir for 10 minutes at that temperature. After completion of the reaction indicated by TLC, the reaction mixture was washed with distilled water (3×7 mL) and extracted with CH
2Cl
2(3×10 mL). The combined organic phase was dried over Na
2SO
4 and after evaporating the solvent, the residue was purified by column chromatography over silica gel using hexane/EtOAc as eluent to provide the pure target product 2-Bromophenol.
