Description
Benzyl-PEG6-alcohol is a PEG linker with a benzyl protecting group and a primary alcohol. The benzyl protecting group can be removed under acidic conditions. The primary alcohol can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
References
[1] Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479. DOI:
10.1016/j.bmc.2019.02.048