Uses
Amino-PEG5-alcohol is a useful research chemical.
Description
Amino-PEG5-alcohol is an aqueousr soluble PEG linker with one amine and one hydroxyl group. The amine group is reactive with carboxylic acids, activated NHS esters etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
IC 50
PEGs; Non-cleavable Linker
References
[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.
