Description
(±)11-
HEPE is produced by non-
enzymatic oxidation of eicosapentaenoic acid. It contains equal amounts of 11(S)-
HEPE and 11(R)-
HEPE. The biological activity of (±)11-
HEPE has not been clearly documented.
Uses
11-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid)[1].
Definition
ChEBI: 11-HEPE is a HEPE that consists of (5Z,8Z,12E,14Z,17Z)-icosapentaenoic acid in which the hydroxy group is located at position 11. It has a role as a rat metabolite. It is functionally related to an all-cis-5,8,11,14,17-icosapentaenoic acid.
References
[1] Kogure R, et al. 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):58-63. DOI:
10.1016/j.bbrc.2011.10.141