4-Methylpyridazine

Chemical Properties

Clear yellow liquid

Uses

4-Methylpyridazine was used in the preparation of series of novel pyridazine derivatives structurally related to bipyridine cardiotonics.

Reactions

4-methylpyridazine could be used as a starting material to synthesize a series of novel pyridazine derivatives structurally related to bipyridine cardiotonics[1].
Pyridazine (pydz) and 4-methylpyridazine (4Me-pydz) could form stable bis(monodentate) complexes of general formulae fac-[PtXMe3L2](X = Cl, Br or I) and fac-[ReX(CO)3L2](X = Cl, Br or I). These complexes in above-ambient temperature solutions exhibit 1,2-fluxional shifts between the nitrogen donor pairs of each ring[2].

General Description

Products of reaction of methyl iodide with 4-methylpyridazine has been investigated by NMR spectra. Solvent free oxidation of 4-methylpyridazine by acetyl peroxyborate, peracetic acid and hydrogen peroxide has been reported.

References

[1] Haider N, et al. Pyridazine analogues of biologically active compounds. Part 5: Novel potential cardiotonics of the amrinone type. Organic Electronics, 1989.
[2] Abel E, et al. 1,2-Metallotropic shifts in trimethylplatinum(IV) and tricarbonylrhenium(I) halide complexes of pyridazine and 4-methylpyridazine. Journal of the Chemical Society, Dalton Transactions, 1994; 445-455.