H-Lys-Glu-OH

Description

H-LYS-GLU-OH (also known as lysylglutamic acid) is a basic dipeptide containing two amino groups and two carboxyl groups. Studies have shown that this compound exerts a significant immunomodulatory effect on both young and aged rat spleen cell cultures, stimulating the proliferation of undifferentiated T lymphocytes (CD5⁺) and B lymphocytes (CD20⁺) [2]. Furthermore, this dipeptide can serve as a starting material for the preparation of various derivatives, including diketopiperazine derivatives and ε-guanidino derivatives [3].

Chemical Properties

White powder

Uses

Lysylglutamic acid is a dipeptide formed by combining two amino acids, Lysine (Lys) and Glutamic acid (Glu). The Ki value of the membrane transporter PEPT1 was 1.3 mM[1].

Definition

ChEBI: A dipeptide formed from L-lysine and L-glutamic acid residues.

References

[1] Biegel A, et al. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DOI:10.1021/jm048982w
[2] Кузнецова Е.П., Костылев А.В., Червякова Н.А. (2013). Пептиды восстанавливают иммуногенез в селезенке при ее старении. Российский семейный врач, 17 (3), 33-36. https://cyberleninka.ru/article/n/peptidy-vosstanavlivayut-immunogenez-v-selezenke-pri-ee-starenii
[3] Greenstein, J. (1900). STUDIES OF MULTIVALENT AMINO ACIDS AND PEPTIDES. 0. https://doi.org/10.1016/s0021-9258(18)75185-5