Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Price

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Chemical Properties,Usage,Production

Physical Form

White to Yellow Solid

Description

Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) butyric acid is an important intermediate for the preparation of sitagliptin. Sitagliptinphosphate is the first dipeptidase -IV(dpp-4) inhibitor approved by FDA in 2006. It is used for the treatment of type II diabetes mellitus. It has obvious hypoglycemic effect when used alone or in combination with metformin and pioglitazone, and it is safe to take, well tolerated, with few adverse reactions.

Uses

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid has been used as a reactant for the preparation of dipeptidyl peptidase-4 (DPP4) inhibitors for the treatment of type 2 diabetes, such as sitagliptin.

Synthesis

(R)-β-tert-butoxycarbonylamino-2,4,5-trifluorophenylbutyric acid ethyl ester could used as a starting material and followed by adding Methanol and LiOHH2O as reaction reagents. Adding dichloromethane to the concentrate and adjust the pH to 2 with 2N HCl. Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid could be obtained through further purification.

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid synthesis

1048703-14-5

486460-00-8

Preparation Products And Raw materials

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid Supplier

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Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

Sinoway Industrial co., ltd.

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Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)-butyric acid

Nanjing Fred Technology Co., Ltd

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BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID

$10.00/ KG

99%

Hebei Weibang Biotechnology Co., Ltd

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