Uses
2,4,5-Trifluorobenzyl chloride is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor that decreases in
glucagon to improve control of blood sugar used for the treatment of
type 1 diabetes, 79% of the dose excreted in the urine.
Synthesis
On the four-neck flask, install a stirrer, a thermometer, a chlorine gas pipe and a reflux condenser. The reflux condenser is connected to the HCl absorption system, and a light source is installed near the flask.Add 146.0g 2,4,5-trifluorotoluene and 3.0g azobisisobutyronitrile into the reaction flask, stir and heat, and when the temperature rises to 110°C, add dry chlorine gas, and Using GC tracking, after about 3h of chlorine gas, stop the halogenating agent chlorine gas, cool the reactant, wash it with water to neutrality, dry and distill under reduced pressure to obtain 2,4,5-trifluorobenzyl chloride.
