CHAETOGLOBOSIN A

Description

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

Occurrence

A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.

Uses

Chaetoglobosin A is a mycotoxic cytochalasan compound.

Definition

ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.

storage

+4°C

References

[1] HE LI. Chaetoglobosins from Chaetomium globosum, an Endophytic Fungus in Ginkgo biloba, and Their Phytotoxic and Cytotoxic Activities[J]. Journal of Agricultural and Food Chemistry, 2014, 62 17: 3734-3741. DOI:10.1021/jf500390h
[2] P B KNUDSEN. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton[J]. Leukemia, 2013, 28 6: 1289-1298. DOI:10.1038/leu.2013.360
[3] C SHINOHARA. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.[J]. Journal of Antibiotics, 2000, 53 3: 262-268. DOI:10.7164/antibiotics.53.262