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Geldanamycin

Geldanamycin Structure
Geldanamycin
  • CAS No.30562-34-6
  • Chemical Name:Geldanamycin
  • CBNumber:CB8462842
  • Molecular Formula:C29H40N2O9
  • Formula Weight:560.64
  • MOL File:30562-34-6.mol
Geldanamycin Property
  • Melting point: :255 °C
  • Boiling point: :627.87°C (rough estimate)
  • Density  :1.2443 (rough estimate)
  • refractive index  :1.5800 (estimate)
  • Flash point: :87℃
  • storage temp.  :−20°C
  • solubility  :DMSO: soluble
  • pka :8.42±0.70(Predicted)
  • form  :powder
  • color  :yellow to orange
  • λmax :305nm(MeOH)(lit.)
  • CAS DataBase Reference :30562-34-6(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :Z3K3VJ16KU
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H303-H227
  • Precautionary statements P210e-P280a-P370+P378a-P403+P235-P501a
Geldanamycin Price More Price(11)
  • Brand: Sigma-Aldrich
  • Product number: 345805
  • Product name : Geldanamycin,
  • Purity: A benzoquinoid antibiotic that inhibits p60
  • Packaging: 100ug
  • Price: $271
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: G3381
  • Product name : Geldanamycin from Streptomyces hygroscopicus
  • Purity: ≥98% (HPLC), powder
  • Packaging: 1mg
  • Price: $572
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: G0334
  • Product name : Geldanamycin
  • Purity: >98.0%(HPLC)
  • Packaging: 10mg
  • Price: $299
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63397
  • Product name : Geldanamycin
  • Purity: 99+%
  • Packaging: 25mg
  • Price: $151
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J67124
  • Product name : Geldanamycin, 1 mg/ml in DMSO, sterile-filtered
  • Purity: 
  • Packaging: 1ml
  • Price: $188
  • Updated: 2020/06/24
  • Buy: Buy

Geldanamycin Chemical Properties,Usage,Production

  • Chemical Properties Yellow to Orange Powder
  • Uses Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.
  • Uses Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. It is a potent antitumour metabolite that acts by binding to the 90-kDa heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT.
  • Definition ChEBI: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
  • Biological Activity Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors.
Geldanamycin Preparation Products And Raw materials
Raw materials
Preparation Products
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30562-34-6, GeldanamycinRelated Search:
  • Geldanamycin from Streptomyces hygroscopicus, ≥98% (HPLC)
  • geldanamycin 30562-34-6
  • GELDANAMYCIN;NSC-122750; NSC 122750; NSC122750
  • Geldanamycin (NSC122750)
  • CS-503
  • Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem
  • [(4Z,6E,8R,9R,10Z,12R,13R,14R,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-9-yl] carbamate
  • (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-[(Aminocarbonyl)oxy]-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21(1)-pentene-3,20,22-trione
  • CP-122634
  • 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate
  • NSC 212518
  • GELDANAMYCIN FROM STRE
  • GeldanaMycin, froM StreptoMyces hygroscopicus var geldanus
  • GeldanaMycin froM StreptoMyces hygroscopi
  • 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate
  • Geldanamycin [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
  • GeldanamyCln
  • Geldanamycin, 99%, from Streptomyces hygroscopicus var geldanus, a HSP90 inhibitor
  • nsc122750
  • GELDANAMYCIN
  • GELDANAMYCIN, STREPTOMYCES HYGROSCOPICUS
  • GA
  • 9,13-DIHYDROXY-8,14,19-TRIMETHOXY-4,10,12,16-TETRAMETHYL-2-AZABICYCLO[16.3.1]DOCOSA-4,6,10,18,21-PENTAENE-3,20,22-TRIONE, 9-CARBAMATE
  • GELDANAMYCIN (GDM)
  • GELDANAMYCIN FROM STREPTOMYCES*HYGROSCOP ICUS
  • GELDANAMYCIN, 99+%
  • Streptomyces hygroscopicus
  • 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
  • [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-Hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
  • [(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
  • Geldanamycin&gt
  • Geldanamycin Geldanamycin
  • 30562-34-6
  • 0562-34-6
  • 562-34-6
  • C29H40N2O9
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